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Trust your gut instinct

By Dr Kathryn O’Sullivan, Nutrition Scientist

 

Focusing on the gut may support our return to normality in more ways than expected.

Scientists think that the bacteria in our gut could be a major weapon in fighting  COVID 19.

 

Hippocrates famously said that all diseases begin in the gut. Fast forward to today and evidence is accumulating that the gut is the cornerstone of the immune system hosting 70-80% of the immune tissue.

 

We are more bacteria than human

 

We have more bacterial than human cells in our bodies and the majority are found in the gut.  In fact, it is estimated that our gut hosts more than 100 trillion microorganisms, ten times the number of human cells!

 

The collective genetic material of bacteria in the gut is known as the microbiome.

A diverse microbiome contains a unique assortment of bacteria, each playing their part in immunity, and the ratio between “good” and “bad” bacteria is strongly influenced by diet, although age, general health and genetics also affect the composition. The gut microbiome exists in a delicate balance, which is key in maintaining a healthy immune system, whereas an abnormal gut microbiome, or imbalance, called dysbiosis can result in the gut microbiome lacking the right bacterial mix and leading to a dysfunctional immune response to infection.  Dysbiosis is more common in old age, obesity, people in poorer health and more recently has been described in severe cases of COVID 19. We know poor health and older age are risk factors for COVID 19. There is a developing view amongst scientists that people at increased risk of COVID 19 may have an altered gut microbiome  (1).

 

Talking Cells

 

Human and bacterial cells have co-evolved to work symbiotically to regulate the  immune system. Scientists use the expression cross-talk to describe the communication between gut microbiomes and immune cells, which ensures that the immune system doesn’t go into overdrive and cause unnecessary damage to the body. In fact, doctors are beginning to think that uncontrolled inflammatory immune responses, rather than the corona virus itself, may be causing the adverse effects of COVID 19 infection on the body.

 

It seems that like the immune system, gut microbiome and the lungs cross-talk too. This is called the gut-lung axis. Gut bacteria elicit immune responses to infections not only in the gut but also the respiratory system, meaning they play a role in protecting the lung from respiratory infections. Studies show that the  gut microbiome can affect the incidence and severity of flu symptoms  and also the effectiveness of flu vaccination may be improved by a healthy gut microbiome. (2)

 

Could altered gut-lung cross-talk play a role in COVID 19?

 

Early on in the pandemic, researchers from Hong Kong reported significantly altered gut microbiome composition in patients with severe COVID 19 and also in recovered patients who experienced what is now being called Long COVID (3)).

 

A scientific review from Korea University suggested altered gut microbiota made it easier for coronavirus to infect cells (4), while scientists in Portugal think dysbiosis could be a predictor of increased susceptibility to severe COVID 19. Like the Hong Kong scientists they think that the microbiome composition is linked to the susceptibility of some patients to progress to severe stages of the disease (5).

 

Research is now concentrating on trying to identify if there is a specific bacterial pattern in the gut microbiome that might predict the clinical outcomes of COVID 19 which could then help doctors to prioritise patients at risk for developing severe disease. Others research is focusing on potential treatments linked to the microbiome. For example, faecal microbiome transplants and dietary changes to beneficially influence the microbiome (4).

Some scientists have even wondered if western countries such as the UK and USA with good medical infrastructures may have been harder hit by coronavirus  because habitual diets tend to be deficient in fibre which may be a reason  for altered gut microbiomes and greater risk of dysbiosis (4)? This is of course emerging science and much further and deeper research is required to understand this complex relationship and draw meaningful conclusions.

 

You are eating for 2…species

 

The good news is that certain foods can quickly modify the gut microbiome to optimise the immune system (6)).

 

The best way to increase microbiome diversity is to eat a wide range of plant foods. The American Gut Project found eating 30 or more types of plants a week results in a  healthier microbiome than eating 10 or fewer. Prebiotic and probiotic foods can also help.

 

Probiotic foods contain live bacteria. Fermented foods like kombucha (fermented tea) ,  Korean kimchi, sauerkraut, miso and  tempeh and cultured dairy foods such as yoghurts and kefir (fermented milk)  can help  restore the composition by  reintroducing  “good” bacteria into the gut.

 

 

Many plant foods contain prebiotics which are types of carbohydrates that only gut bacteria can feed upon. They selectively stimulate the colonisation of the “good” bacteria in the gut microbiome. In some respects, prebiotics feed probiotics! Artichokes, chickpeas, asparagus, edamame beans,  bananas, berries, tomatoes, garlic, onions, legumes, green vegetables and wholegrain cereals and fermented and pickled foods  have prebiotic properties.  Cooking grains like rice and pasta and then allowing them to cool increases the level of resistant starch which is a prebiotic. While pre and probiotics can be found in foods, supplements are also available

 

When it comes to eating out opt for going Asian. A study comparing typical American and Korean diets on gut microbiomes found that four weeks on the Korean diet dramatically and beneficially changed the gut microbiome probably owing to it being more plant based with a greater consumption of fermented foods like kimchi compared to a typically lower in fibre more animal based American diet (7).

 

Eating less sugar and overly processed foods as well are avoiding taking antibiotics unnecessarily, exercising regularly and making sure you get enough sleep will also help improve the gut microbiome and enhance overall health.

 

Gut to know yourself

 

Home tests are now readily available to measure gut microbiomes. Using bacterial DNA sequencing tests like INTEST.pro  offer the opportunity to tailor our diets to ensure our gut bacteria mix is at its most advantageous. The gut microbiome is adaptable and while dietary changes can beneficially alter it,  changes in composition may be only  temporary if we change our diet again. Home tests can be useful in providing baseline readings which can then be used as a monitor to maintain or tweak the diet to a healthy and diverse microbiome. While dietary advice to improve gut health, certainly will benefit us all, home tests can offer reassurance that it is working !

 

Key takeaway messages

 

Human and bacterial cells have co-evolved to work symbiotically to regulate the immune system

 

In dysbiosis, when the gut bacteria are out of balance, cross-talk between the bacteria and immune cells is affected resulting in reduced immunity and illness.

 

A gut friendly diet encourages the good bacteria to dominate and therefore a healthy balance of bacteria in the gut.

 

Gut dysbiosis has been identified in patients with severe COVID and while there is currently no treatment for COVID 19, promoting dietary changes to beneficially influence the gut microbiome could be a non-medical way of supporting the recovery of severe and long COVID 19.

 

 

As the old saying goes, you are what you eat!

 

swap one staple food for a gut helpful alternative.

 

  • Coleslaw with kimchi or sauerkraut
  • Hot pasta with cold pasta salad
  • Hot pasta with cold noodle salad
  • boiled rice with sushi or sticky rice
  • White bread with sour dough or wholegrain
  • Pasta bolognaise with vegetable pasta
  • soda drinks with kombucha
  • ice cream with probiotic yoghurt and fruit
  • milk with kefir
  • crisps with roasted chickpeas, nuts or seeds
  • cheese and biscuits with veg sticks and hummus or guacamole
  • cheddar with blue cheese
  • sugar breakfast cereals with high fibre or muesli varieties
  • chocolate with whole nut chocolate
  • Adapt a flexitarian approach and split your week into meat and meat free days
  • Load up with vegetables and fruit at every opportunity, in pastas, pizzas, stir fry, sandwiches, deserts
  • Think diversity and plants
  • Invest in probiotic or prebiotic supplements

 

 

References

 

  • https://nutrition.bmj.com/content/3/1/74
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790137/

 

(3). https://gut.bmj.com/content/70/4/698

 

(4).  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7845625/

 

(5).  https://www.mdpi.com/2076-2607/9/1/53/htm

 

(6). https://www.nature.com/articles/nature12820

(7). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6835328/

 

 

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  • Bereaved parents attend Westminster event to help launch a hard-hitting new ad campaign to raise awareness of sudden cardiac death
  • Pioneering pilot study takes the “puff” away from the E-cigarette debate- and replaces it with real research
  • Medical experts debate acute hospital care at key conference
  • Harley Street Fertility Clinic’s Dr Venkat to have a weekly slot on BBC Asain Network
  • Health Secretary, Jeremy Hunt and one of UK’s best known musicians, Suggs, show support for Pancreatic Cancer research
  • Destination Diabetes: – celebrating the arrival of the London Diabetes Care Plan
  • Trinity PR works alongside national charity during annual awareness week to call for greater understanding of issues faced by young people living with Dyspraxia
  • New campaign to help tackle the issue of medication non-adherence
  • Menopause month: Tackling Taboos
  • Daughter raises funds for nursing home in memory of late father
  • Webchat with HSFC director Dr Venkat and Mother & Baby Magazine
  • Trinity PR supports Pancreatic Cancer awareness month this November
  • Trinity takes to the Heart of London for annual fundraising event
  • Happy Anniversary NHS!
  • Beautiful Beetroot
  • Sibling Support
  • Skills for Health Media Bulletin
  • Treatment for BRCA Gene Mutation
  • We are moving
  • Abraxane for the treatment of advanced pancreatic cancer added to National Cancer Drugs Fund List
  • National Apprenticeship Week (3-7 March 2014)
  • Pancreatic Cancer UK launches “two more months” campaign ahead of crucial decision by The Cancer Drugs Fund
  • Trinity PR adds exciting new client from the medical device sector to its current portfolio
  • The Heartbreaking Agony Of Losing A Partner Before The Age Of 35
  • We’re looking for a new Trainee PR Account Executive
  • Raising awareness of egg donation within the Asian community
  • Excellence in compliance saluted across London NHS Trusts

2013

  • In celebration of the festive season, Trinity PR developed a popular sprouts story that captured the media’s attention
  • Pancreatic Cancer: Time to change the story
  • BSIR annual meeting 2013: Conference news- amputation rates too high experts warn on world Diabetes day!
  • Digital vs. Traditional – it’s all in the mix for PR agency selection
  • Don’t hang up on Dyspraxia
  • Trinity PR embarks on new working partnership with Steadfast Clinics Ltd
  • Millions of patients given new hope of beating their back pain: 40 % could be cured with antibiotics
  • Rebuilding faces, mending smiles; the life changing work of Project Harar
  • One day all this will be yours…
  • Health News Watch: Tackling the “Big 5”
  • Get a sprint on this spring in aid of help for heroesget a sprint on this spring in aid of help for heroes
  • Don’t let the winter chill freeze your back

2012

  • Have a fertile New Year!
  • Cardiac Risk in the Young (CRY) 10th Parliamentary Reception
  • Women applaud on-going development of techniques that let them to say ‘no’ to hysterectomy
  • Competition hots up in the Gulf…
  • Trinity: the midas touch
  • We’re in!
  • Is Telehealth the answer?
  • Cataract surgery access slammed
  • Don’t let asthma hold you back…follow the Olympic lead
  • Calls for urgent review of cardiac screening policy among black athletes
  • The Sunshine Vitamin: Are you getting enough vitamin D?
  • The Middle East Market
  • Guild of Health Writers
  • Newlife: raising the bar in reproductive health
  • Cardiac screening in the young soars overnight as Fabrice Muamba hits the headlines
  • Trinity supports The London Clinic’s clinical trial and patient recruitment programme
  • Our website
  • Hello Dubai!
  • Super sprint
  • Call for increased access to clinical trial data
  • Charities’ tax relief fears
  • Hope on the Horizon…
  • Sign-up in support of screening

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